Tuesday 11 September 2018
16.45 – 18.00
EMBO Session
Welcome and Opening session
Chair:
Maria Leptin (EMBO, Heidelberg, Germany)
16.45
Welcome
Josef Helfenstein (Kunstmuseum Basel, Basel, Switzerland)
Susan Gasser (Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland)
Gerd Folkers (ETH, Zürich, Switzerland)
17.00
Art and Science
Michael N. Hall (University of Basel, Switzerland)
Jacques Herzog (Herzog & de Meuron, Basel, Switzerland)
Basel Kunstmuseum
18.00 – 19.30
EMBO Session
Welcome reception
Attendees are invited to visit the art galleries of the museum (18:30 – 19:30, free admission)
Discover the art galleries of the Kunstmuseum: Ask Me Guides will be happy to answer your questions.
Basel Kunstmuseum
Wednesday 12 September 2018
09.00 – 09.45
EMBO Scientific Session
Keynote lecture 1
Chair:
René Bernards (Netherlands Cancer Institute, Amsterdam, Netherlands)
09.00
Novel therapeutic approaches
Jeffrey Engelman (Novartis, Boston, United States)
Montreal
09.45 – 10.15
Coffee break at the exhibition
10.15 – 12.00
EMBO Scientific Session
Plenary session 1: Cancer I
Chair:
René Bernards (Netherlands Cancer Institute, Amsterdam, Netherlands)
10.15
Tumour-stroma interactions in breast cancer metastasis
Clare Isacke (The Institute of Cancer Research, London, United Kingdom)
10.40
Translation control in melanoma
Caroline Robert (Institut Gustave Roussy, Paris, France)
11.05
Cancer evolution as a therapeutic target
Alberto Bardelli (University of Torino, Candiolo, Italy)
11.30
Cell plasticity and lineage commitment in liver tumorigenesis
Lars Zender (Tübingen University, Germany)
Montreal
12.00 – 13.45
Lunch break
13.45 – 15.30
EMBO Scientific Session
Parallel session 1: Plant disease and pathogens
Chair:
Regine Kahmann (Max Planck Institute for Terrestrial Microbiology, Marburg, Germany)
13.45
Effectors to go: unexpected insights from a plant pathogenic fungus
Regine Kahmann (Max Planck Institute for Terrestrial Microbiology, Marburg, Germany)
14.10
Dynamics of host adaptation in fungal pathogens
Antonio Di Pietro (University of Cordoba, Cordoba, Spain)
14.35
Secretion and delivery of effector proteins from a plant pathogen to its host
Paul Birch (The James Hutton Institute, Dundee, United Kingdom)
15.00
Determination of the host range of the fungal plant pathogen Verticillium
Bart Thomma (University of Wageningen, Netherlands)
Montreal
13.45 – 15.30
EMBO Scientific Session
Parallel session 2: Cancer II
Chair:
Charles Swanton (The Francis Crick Institute, London, United Kingdom)
13.45
Cancer evolution, adaptation and immune evasion
Charles Swanton (The Francis Crick Institute, London, United Kingdom)
14.10
Understanding the role of metabolism in cancer
Matthew G. Vander Heiden (Koch Institute for Integrative Cancer Research, Cambridge, United States)
14.35
Circulating tumour cells: a multi-use biomarker
Caroline Dive (The University of Manchester, United Kingdom)
Abstract presentations
15.00
The protein histidine phosphatase LHPP is a tumor suppressor
S.K. Hindupur1, M. Colombi1, S.R. Fuhs2, M.S. Matter3, Y. Guri1, K. Adam2, M. Cornu1, S. Piscuoglio3, C.Y. Ng3, C. Betz1, D. Liko1, L. Quagliata3, S. Moes1, P. Jenoe1, L.M. Terracciano3, M.H. Heim4, T. Hunter2, M.N. Hall1
1University of Basel / Biozentrum, Basel, Switzerland, 2Salk Institute for Biological Studies, California, CA, United States, 3Universitätsspital Basel / Institute of Pathology, 4Universitätsspital Basel / Department of Biomedicine, Basel, Switzerland
15.15
Modelling mutant IDH2 leukemia evolution identifies vulnerabilities and effective combination therapy
V. Mugoni1,2, R. Panella1, G. Cheloni1, M. Chen1, O. Pozdnyakova3, D. Stroopinsky1, J. Guarnerio1, E. Monteleone1,4, J.D. Lee1, L. Mendez1, A. Venugopal Menon1, J.C. Aster3, A. Lane5, R.M. Stone5, I. Galinsky5, J.C. Zamora6, F. Lo-Coco7,8, M.K. Bhasin9, D. Avigan1, L. Longo1, J. Clohessy1,2,10, P.P. Pandolfi2
1Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA., 2Ludwig Center at Harvard, Harvard Medical School, 3Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States, 4Molecular Biotechnology Center and Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy, 5Department of Medical Oncology, Dana-Farber Cancer Institute; Harvard Medical School, Boston, MA, United States, 6Biobanco La Fe - Instituto de Investigation Sanitaria La Fe (IIS-LA FE), Valencia, Spain, 7Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', 8Neuro-Oncohematology Unit, Santa Lucia Foundation, Rome, Italy, 9Division of IMBIO, Department of Medicine, BIDMC Genomics, Proteomics, Bioinformatics and Systems Biology Center, Harvard Medical School and Beth Israel Deaconess Medical Center, 10Preclinical Murine Pharmacogenetics Core, Beth Israel Deaconess Cancer Center, Dana Farber/Harvard Cancer Center, Boston, MA, United States
Singapore
15.30 – 16.30
EMBO Flash Talks & Posters
EMBO Flash talks (session 1)
Cancer
15.30 P110
Mechanisms of oncogene-induced DNA replication stress
M. Macheret, T.D. Halazonetis
Molecular Biology, University of Geneva, Geneva, Switzerland
15.34 P111
DNA-PK regulates the radiosensitivity and oncogenicity of MET-addicted cancer cell lines via a novel MET phosphosite
J. Koch1, S.M. Roth1, A. Quintin1, J. Gavini2, E. Orlando1, M. Medo1, R. Aebersold3,4, D.M. Stroka2, D.M. Aebersold1, Y. Zimmer1, M. Medová1
1Department for BioMedical Research, Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, 2Department for BioMedical Research, Visceral Surgery, Inselspital, Bern University Hospital and University of Bern, Bern, 3Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, 4Faculty of Science, University of Zürich, Zürich, Switzerland
15.38 P112
The mammalian Target of Rapamycin Complex 2 (mTORC2) promotes tumorigenesis via lipid synthesis
Y. Guri1, M. Colombi1, E. Dazert1, S. Kumar1, S. Moes2, P. Jenoe2, J. Roszik3, M. Heim4, H. Riezman5, I. Riezman5, M.N. Hall1, Biozentrum, University of Basel, Basel, Switzerland
1Biozentrum | Growth and Development, University of Basel, 2University of Basel / Biozentrum, Basel, Switzerland, 3Melanoma Medical Oncology and Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States, 4Hepatology, Universitätsspital Basel, Basel, 5University of Geneva, Geneva, Switzerland
15.42 P113
Molecular mechanisms mediating responsiveness to targeted cancer therapy
E. Dazert1, M. Colombi1, T. Boldanova2, C. Etter1, C.K.Y. Ng3, T. Habluetzel1, S. Wieland2, S. Ketterer2, T. Bock1, S. Moes1, P. Jenoe1, A. Schmidt1, L. Terracciano3, M. Heim2, M.N. Hall1
1Biozentrum / University of Basel, 2Department of Biomedicine / University Hospital Basel, 3Molecular Pathology / University Hospital Basel, Basel, Switzerland
15.46 P114
A highly miniaturized system for anti-cancer compound screening on primary cells and cancer spheroids
A. Popova1, S. Dietrich2, P. Levkin1
1Institute for Toxicology and Genetics, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, 2Hematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany
15.50 P115
Role of CDK8 in hepatocellular carcinoma
K. Bacevic, S. Prieto, J. Ursic-Bedoya, C. Dohet, A. Camasses, D. Fisher, U. Hibner, D. Gregoire
Institute of Molecular Genetics, Montpellier, France
15.54 P116
Potassium channels and membrane polarization control membrane translocation of cell-penetrating peptides
E. Trofimenko1, M. Heulot1, N. Chevalier1, S. Michel1, M. Serulla Llorens1, G. Vantomme2, Y. Arribat1, G. Dubuis1, J. Puyal2, F. Amati1, A. Luthi2, C. Widmann1
1Department of Physiology, 2Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland
Metabolic disorders – diabetes/obesity
15.58 P117
Insulin resistance causes inflammation in adipose tissue
M. Shimobayashi1, V. Albert1, B. Woelnerhanssen2, I.C. Frei1, D. Weissenberger1, A.C. Meyer-Gerspach2, N. Clement2, S. Moes1, M. Colombi1, J.A. Meier1, M.M. Swierczynska1, P. Jenö1, C. Beglinger2, R. Peterli1, M.N. Hall1
1University of Basel / Biozentrum, 2St. Claraspital, Basel, Switzerland
16.02 P118
Lipid metabolism and intestinal organoid development
A. Xavier da Silveira dos Santos1, F. Maurer1, S. Iftkhar1,2, K. Volkmann1, C. Genoud1, P. Liberali1
1Quantitative Biology, Friedrich Miescher Institute for Biomedical Research, 2Biozentrum / University of Basel, Basel, Switzerland
Inflammation
16.06 P119
T cell costimulation blockade blunts pressure overload-induced heart failure
E. Martini1, M. Kallikourdis1,2, P. Carullo3,4, C. Sardi1, C.M. Greco3, G. Roselli1, F. Riva5, A.M. Ormbostad Berre6, T.O. Stølen6, A. Fumero7, G. Faggian8, E. Di Pasquale3,4, L. Elia3, C. Rumio9, D. Catalucci4,10, R. Papait3, G. Condorelli2,3
1Adaptive Immunity Laboratory, Humanitas Research Hospital, 2Department of Biomedical Sciences, Humanitas University, 3Department of Cardiovascular Medicine, Humanitas Research Hospital, 4Institute of Genetic and Biomedical Research (IRGB), National Research Council of Italy, Rozzano, 5Department of Veterinary Sciences and Public Health (DIVET), University of Milan, Milano, Italy, 6Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway, 7Cardiac Surgery, Humanitas Research Hospital, Rozzano, 8Department of Cardiac Surgery, University of Verona, Verona, 9Dipartimento di Scienze Farmacologiche e Biomolecolar, University of Milan, Milano, 10Laboratory of Signal Transduction in Cardiac Pathologies, Humanitas Research Hospital, Rozzano, Italy
Neurodegenerative disease
16.10 P120
In vitro Labeling of Human Wharton's Jelly-derived Mesenchymal Stem Cells with Dextran-coated Superparamagnetic Iron Oxide Nanoparticles by a New Bio-Mimicry Method
M. Mehdizadeh1, R. Shabani2, F. Ghiami2
1Cellular and Molecular Research Center, Faculty of Advanced Technologies in Medicine, Department of Anatomical Sciences, 2Department of Anatomical Sciences, School of Medicine, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran
16.14 P121
Comparative in silico analysis of bacterial and human neutral sphingomyelinases
B. Yagci, E. Ozkirimli Olmez, K. Ulgen
Chemical Engineering, Bogazici University, Istanbul, Turkey
MipTec stage
15.30 – 16.30
EMBO Poster Session
EMBO Poster session 1
Poster exhibition
16.30 – 17.30
EMBO Scientific Session
Louis-Jeantet Prize lectures
Chair:
Paul Nurse (The Francis Crick Institute, London, United Kingdom)
16.30
Deconstructing and reconstructing the vasculature
Christer Betsholtz (Uppsala University, Sweden)
17.00
Dissecting human antibody responses: useful, basic and surprising findings
Antonio Lanzavecchia (Institute for Research in Biomedicine, Bellinzona, Switzerland)
Montreal
Thursday 13 September 2018
09.00 – 09.45
EMBO Scientific Session
Keynote lecture 2
Chair:
Karen Avraham (Tel Aviv University, Israel)
09.00
Space and memory in the brain
May-Britt Moser (NTNU, Trondheim, Norway)
Montreal
09.45 – 10.15
Coffee break at the exhibition
10.15 – 12.00
EMBO Scientific Sessions
Plenary session 2: Microbial disease and pathogens
Chair:
Philippe Sansonetti (Insitut Pasteur, Paris, France)
10.15
Gut microbiome and intestinal epithelial regeneration: decrypting signals in the crypt
Philippe Sansonetti (Insitut Pasteur, Paris, France)
10.40
Pathoecology and evolution of the cholera-causing pathogen Vibrio cholerae
Melanie Blokesch (EPFL, Lausanne, Switzerland)
11.05
Programmable RNA antibiotics for microbiome editing
Jörg Vogel (Helmholtz Centre for Infection Research, Germany)
11.30
How Salmonella deals with host immune responses
David Holden (Imperial College London, United Kingdom)
Montreal
12.00 – 13.45
Lunch break
13.45 – 15.30
EMBO Scientific Session
Parallel session 3: Microbiota
Chair:
François Leulier (IGFL, Lyon, France)
13.45
The microbiome and animal linear growth promotion
François Leulier (IGFL, Lyon, France)
14.10
Personalizing treatments using microbiome and clinical data
Eran Segal (Weizmann Institute of Science, Rehovot, Israel)
14.35
tba
Ami Bhatt (Stanford University, Palo Alto, United States)
15.00
Innovation in nutrition and health based on microbiome research
Nathalie Delzenne (UCLouvain/Louvain Drug Research Institute, Brussels, Belgium)
Montreal
13.45 – 15.30
EMBO Scientific Session
Parallel session 4: Sensory function and deficit
Chair:
Karen Avraham (Tel Aviv University, Israel)
13.45
Epigenomics of the auditory system: Implications for deafness
Karen Avraham (Tel Aviv University, Israel)
14.10
Gut feelings: delineating sensory signaling pathways in the intestine
David Julius (University of California, San Francisco, United States)
14.35
Optogenetics for vision restoration - translation from mice to primates
Deniz Dalkara (Institut de la Vision, Paris, France)
15.00
Cell type specification during development of proprioception - the body's 'Sixth Sense'
Yoram Groner (The Weizmann Institute of Science, Rehovot, Israel)
Singapore
15.30 – 16.00
Coffee break at the exhibition
16.00 – 17.15
EMBO Scientific Session
Plenary session 3: Inflammation
Chair:
Yinon Ben-Neriah (The Hebrew University Hadassah Medical School, Jerusalem, Israel)
16.00
CKI alpha inhibition-mediated p53 activation and parainflammation – implications for cancer therapy
Yinon Ben-Neriah (The Hebrew University Hadassah Medical School, Jerusalem, Israel)
16.25
Inflammation: linking homeostasis and defense
Ruslan Medzhitov (Yale University, New Haven, United States)
16.50
Immune suppression: how to convert conventional T cells into regulatory T cells
Shimon Sakaguchi (Osaka University, Japan)
Montreal
17.30 – 18.30
EMBO Flash Talks & Posters
EMBO Flash talks (session 2)
Microbiota
17.30 P122
Cancer Cell-Microbiota Interactions in the Human Skin Microbiome of Cutaneous T Cell Lymphoma
C. Dehner, W. Ruff, F. Foss, M. Girardi, M. Kriegel
Yale School of Medicine, New Haven, CT, United States
17.34 P123
Experimental evolution of a fungal pathogen into a gut symbiont
G.H.W. Tso1, J.A. Reales-Calderon1, A.S.M. Tan1, X.H. Sem1, G.T.T. Le1, T.G. Tan1, G.C. Lai1, K.G. Srinivasan1, M. Yurieva1, W. Liao1, M. Poidinger1, F. Zolezzi1, G. Rancati2, N. Pavelka1
1Singapore Immunology Network (SIgN), Agency of Science, Technology and Research (A*STAR), 2Institute of Medical Biology, Agency of Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #05, Singapore, Singapore
Aging/senescence
17.38 P124
Identifying the multidimensional controllers of aging
S. Maudsley1, J. van Gastel1, H. Leysen2, J. Hendrickx1
1Department of Biomedical Sciences, VIB - University of Antwerp, 2Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
17.42 P125
mTOR regulates mRNA metabolism via mRNA binding proteins
S. Shetty, M.N. Hall
Biozentrum, University of Basel, Basel, Switzerland
17.46 P126
Sarcopenia chronicles: dynamics of gene expression during aging of rat skeletal muscles
A. Börsch1, J. Feige2, M. Rüegg1, M. Zavolan1
1Biozentrum, University of Basel, Basel, 2Nestlé Institute of Health Sciences, Lausanne, Switzerland
Model systems in disease
17.50 P127
Single cell RNA sequencing identifies novel cell types and distinct, transcriptional programs in the developing Drosophila ovary.
M. Slaidina, T. Banisch, R. Lehmann
Skirball Institute, New York University School of Medicine, New York, NY, United States
17.54 P128
The role for coronin 1 in homeostatic CD4+ T cell expansion and survival in peripheral lymphoid organs
M. Mori, J. Ruer-Laventie, J. Pieters
Biozentrum, University of Basel, Basel, Switzerland
Microbial disease/pathogens
17.58 P129
NCS1 regulates Ca2+-Dependent Focal Exocytosis of Golgi-derived Vesicles to Help Phagocytic uptake in Macrophages
N. Vashi1,2
1National Insstitute of Immunology, Delhi, 2International Centre for Genetic Engineering & Biotechnology, New Delhi, India
18.02 P130
A strategic application of computational tools for the identification enoyl-acyl carrier protein reductase inhibitors
M.Y. Lone1,2, A. Manhas2, P.C. Jha3
1Department of Chemistry, Indian Institute of Technology Gandhinagar, 2School of Chemical Sciences, 3Centre for Applied Chemistry, Central University of Gujarat, Gandhinagar, India
18.06 P131
Conformational Sampling of the Intrinsically Disordered C-Terminal Tail of DERA Is Important for Enzyme Catalysis
M. Schulte1,2, D. Petrovic2, P. Neudecker1,2, R. Hartmann2, J. Pietruszka3,4, S. Willbold5, D. Willbold1,2, V. Panwalkar1,2
1Institut für Physikalische Biologie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, 2Institute of Complex Systems 6, Forschungszentrum Jülich, Jülich, 3Institute of Bioorganic Chemistry, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, 4Institute of Bio- and Geosciences 1: Biotechnology, 5Central Institute of Engineering, Electronics and Analytics, Forschungszentrum Jülich, Jülich, Germany
18.10 P132
Uptake of pVEC Examined by Microfluidic Technology
M. Yuce1, K. Ulgen1, B. Sariyar Akbulut2, E. Ozkirimli Olmez1
1Chemical Engineering, Bogazici University, 2Bioengineering, Marmara University, Istanbul, Turkey
18.14 P133
A Microfluidic Device to Study Chemotaxis by High-Throughput Single-Cell Tracking
F. Wyss, M. Sangermani, U. Jenal
University of Basel / Biozentrum, Basel, Switzerland
Poster exhibition
17.30 – 18.30
EMBO Poster Session
EMBO Poster session 2
Poster exhibition
Friday 14 September 2018
09.00 – 10.15
EMBO Scientific Session
Plenary session 4: Neurodegenerative Disease
Chair:
John Hardy (University College London, United Kingdom)
09.00
Presenilin metastability in Alzheimer’s disease, implications for drug discovery
Lucía Chávez Gutiérrez (Catholic University Leuven, Leuven, Belgium)
09.25
Microglial dysfunction in neurodegenerative disorders
Christian Haass (Ludwig-Maximilians-University, Munich, Germany)
09.50
Gene silencing therapy for human neurodegenerative disease
Don W. Cleveland (Ludwig Institute for Cancer Research, La Jolla, United States)
Montreal
10.15 – 10.45
Coffee break at the exhibition
10.45 – 12.30
EMBO Scientific Session
Parallel session 5: Aging and senescence
Chair:
Judith Campisi (Buck Institute for Research on Aging, Novato, United States)
10.45
Cellular senescence, aging and longevity
Judith Campisi (Buck Institute for Research on Aging, Novato, United States)
11.10
Senescence in cancer therapy – not too bad, if not for good
Clemens A. Schmitt (Max Delbrück Center for Molecular Medicine, Berlin, Germany)
11.35
An integrated view of cellular senescence and in vivo reprogramming
Manuel Serrano (Institute for Research in Biomedicine, Barcelona, Spain)
Abstract presentations
12.00
Longitudinal analysis of gene expression reveals widespread pleiotropic antagonism during aging of the short-lived fish Nothobranchius furzeri.
M. Mazzetto1,2, M. Baumgart2, M. Groth2, A. Martirosyan2, M. Ermolaeva2, M. Platzer2, A. Cellerino1,2
1Scuola Normale Superiore, Pisa, Italy, 2Fritz-Lipmann Institute, Jena, Germany
12.15
Identification and application of gene expression signatures of lifespan-extending interventions
A. Tyshkovskiy1,2, R.A. Miller3, V.N. Gladyshev1
1Division of Genetics, Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA, United States, 2Center for Data-Intensive Biomedicine and Biotechnology, Skolkovo Institute of Science and Technology, Moscow, Russian Federation, 3Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor, MI, United States
Montreal
10.45 – 12.30
EMBO Scientific Session
Parallel session 6: Model systems in disease
Chair:
Cayetano Gonzalez (Institute for Research in Biomedicine, Barcelona, Barcelona, Spain)
10.45
Using Drosophila tumours to understand malignant and normal growth during development
Cayetano Gonzalez (Institute for Research in Biomedicine, Barcelona, Barcelona, Spain)
11.10
Models and model systems: the nutritional geometry of health and ageing
Stephen Simpson (University of Sydney, Sydney, Australia)
11.35
When the young die old: the premature aging disease Progeria and Lamin A processing by ZMPSTE24
Susan Michaelis (Johns Hopkins University, Baltimore, United States)
Abstract presentations
12.00
Active chromatin markers H3K36me and MRG-1 drive heterochromatin spatial sequestration in differentiated cells in C. elegans
D.S. Cabianca1, C. Muñoz Jiménez2, V. Kalck1, D. Gaidatzis1, J. Padeken1, A. Seeber1, P. Askjaer2, S.M. Gasser1
1Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland, 2Andalusian Center for Developmental Biology, Sevilla, Spain
12.30
Human brain organoids with functional eyecups
J. Gopalakrishnan
University of Cologne, Cologne, Germany
Singapore
12.25 – 14.00
Lunch break
14.00 – 15.40
EMBO Scientific Session
Plenary session 5: Metabolic disorders – Diabetes and obesity
Chair:
Helena Edlund (University of Umeå, Sweden)
14.00
PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type2 diabetes patients
Helena Edlund (University of Umeå, Sweden)
14.25
Obesity and its metabolic consequences: lessons from human genetics
Stephen O'Rahilly (University of Cambridge, United Kingdom)
14.50
MicroRNAs and RNA-binding proteins as regulators of metabolism
Markus Stoffel (ETH, Zurich, Switzerland)
15.15
Adipose tissue expandability, lipotoxicity and the metabolic syndrome
Antonio Vidal-Puig (University of Cambridge, United Kingdom)
Montreal
15.40 – 15.55
EMBO Session
Closing address
Montreal
Subject to change.