09.00 – 09.45

Joint Session

Keynote lecture 1: The Genetics of Common Diseases
Kari Stefánsson (deCODE Genetics, Reykjavik, ISL)

Chair: Geneviève Almouzni (Institut Curie, Research Center UMR 3664 CNRS, Paris, FR)

Montreal

10.00 – 11.45

EMBO Scientific Session

EMBO Plenary session 1: Microbiome as a driver of health and disease

Chair: Yasmine Belkaïd (Bethesda, US)

10.00
Host Micro Biome interactions in health and disease
Eran Elinav (Weizmann Institute of Science, Rehovot, IL)

10.25
Microglia at the crossroads of brain circuits and environmental signals
Sonia Garel (PSL Research University, Paris, FR)

10.50
Small molecules from the human microbiota
Michael A. Fischbach (UCSF, San Francisco, US)

11.15
Microbiota control of tissue immunity and repair
Yasmine Belkaïd (Bethesda, US)

Montreal

11.45 – 13.15

Lunch break

13.15 – 15.00

EMBO Scientific Session

EMBO Plenary session 2: The emergence of infectious diseases

Chair: Elena A. Levashina (Vector Biology Unit Max Planck Institute for Infection Biology, Berlin, DE)

13.15   
Digital Epidemiology
Marcel Salathé (EPFL, Geneve, CH)

13.40
Experimental and Computational Approaches for Manipulating Virus Evolution and Population Dynamics
Marco Vignuzzi (Institut Pasteur, Paris, FR)

14.05                  
Title to be announced
Elena A. Levashina (Vector Biology Unit Max Planck Institute for Infection Biology, Berlin, DE) 

14.30                  
Title to be announced
Rino Rappuoli (GSK Vaccines, Siena, IT)

Montreal

15.30 – 16.30

Joint Session

EMBO & [BC]2 Flashtalks on the stage

Stage

16.30 – 17.30

Joint Session

Louis-Jeantet Prize lectures

Chair:
Paul Nurse (The Francis Crick Institute, London, United Kingdom)

16.30                 
Advanced Genetic Engineering of Hematopoiesis to Treat Human Diseases
Luigi Naldini (San Raffaele Telethon Institute for Gene Therapy, Milan, IT)

17.00
Restoring Vision
Botond Roska (Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, CH)

Montreal

15.30 – 16.30

EMBO Session

Networking event & Poster session for EMBO and [BC]2 Presenters

Stage

09.00 – 09.45

Joint Session

Keynote lecture 2: Michal Schwartz (Weizmann Institute of Science, Rehovot, ISR)

Chair: Caetano Reis e Sousa (Immunobiology Laboratory The Francis Crick Institute, London, UK)

Montreal

10.00 – 11.45

EMBO Scientific Sessions

EMBO Plenary session 3: EMM lecture and awards

Chair: Philippe Sansonetti & Céline Carret

10.00
A new way to look at Alzheimer’s Disease: the cellular phase
Bart de Strooper (VIB Center for Brain & Disease Research, UK Dementia Research Institute, Leuven, BE)

EMM 10th anniversary award for posters and one speaker per topical session

10.40
Integrated stress response remodels macrophage immune-metabolism to propagate chronic inflammation and atherosclerosis
Ebru Erbay, Cedars-Sinai Medical Center, Los Angeles, USA)

10.50
Detecting the mutational signature of homologous recombination deficiency in clinical samples
Doga C. Gulhan, Harvard Medical School, Boston, United States

11.00
Suppression of arginine catabolism promotes liver cancer
Dirk Mossmann, Biozentrum, University of Basel, Basel, Switzerland

11.10
Penile microbiota of heterosexual black South African men and analysis of abundances of bacteria associated with HIV risk
Harris Onywera, University of Cape Town, Cape Town, South Africa

11.20    
Vitamin D modulates macrophage polarization and ER stress in lung inflammation and injury targeting miR-34a/Sirt1 axis
Mansoor Syed, Jamia Millia Islamia, New Delhi, India

11.30
Award

Montreal

11.45 – 13.15

Lunch break

13.15 – 15.00

EMBO Scientific Session

EMBO Plenary session 4:Chronic inflammation: The common denominator of post-modern pathologies

Chair: Alberto Mantovani (Istituto Clinico Humanitas, Milan, IT)

13.15
Trained immunity: potential target in immune-mediated diseases
Mihai G. Netea (Radboud University Medical Center, Nijmegen, NL)

13.40
Neuronal regulation of innate lymphocytes
Henrique Veiga-Fernandes (Centro Champalimaud, Lisbon, PT)

14.05
T cell metabolism in infection and cancer
Erika Pearce (Max Planck Institute for Immunobiology and Epigenetics, Freiburg, DE)

14.30
Molecular pathways linking innate immunity, inflammation and cancer
Alberto Mantovani (Istituto Clinico Humanitas, Milan, IT)

Montreal

15.30 – 17.15

EMBO Scientific Session

EMBO Plenary session 5: Regenerative medicine

Chair: Alain Fisher (Institut Imagine, Paris, FR)

15.30
Mendelian genetics of autoimmunity 
Alain Fischer (Institut Imagine, Paris, FR)

15.55
Human type I interferonopathies
Yanick J. Crow (MRC Institute of Genetics & Molecular Medicine, Edinburgh, UK)

16.20
Cellular plasticity in cardiovascular regeneration and aging
Stefanie Dimmeler (Centre for Molecular Medicine, Frankfurt , DE)

16.45
Epigenetic regulation in development, aging and disease
Rudolf Jaenisch (Whitehead Institute for Biomedical Research, Cambridge, USA)

Montreal

09.00 – 10.15

Joint session [BC]²/EMBO

Plenary session 6: Computational biology, artificial intelligence and machine learning in precision medicine

Chair: Jan Korbel (Genome Biology Unit EMBL, Heidelberg, DE)

09.00
Machine learning approaches for elucidating complex gene-environment interactions
Oliver Stegle (European Bioinformatics Institute, Hinxton, UK)

09.25
Understanding chronic blood diseases using millions of electronic health records and single cell genomics
Amos Tanay (Rehovot, ISR)

09.50
Pinpointing disease-causing regulatory genetic variants by multi-omics and machine learning
Julien Gagneur (Fakultät für Informatik, Technische Universität München, Munich, DE)

10.15
Coffee break

Montreal

10.45 – 12.30

EMBO Scientific Session

Plenary session 7 - Genetic diseases: genome and epigenome

Chair: Kristian Helin (Memorial Sloan Kettering Cancer Center, New York, USA)

10.45
Unraveling the acute stress response in bony vertebrates
Gérard Karsenty (Columbia University Medical Center, New York, USA)

11.10
Combined cell and gene therapy for Epidermolysis Bullosa
Michele De Luca (Università degli Studi di Modena e Reggio Emilia, Modena, IT)

11.35
Why are diseases tissue-specific? Lessons from mitochondrial diseases
Anu Suomalainen (University of Helsinki, Helsinki, FI)

12.00
Epigenetics in transcriptional control, development and cancer
Kristian Helin(Memorial Sloan Kettering Cancer Center, New York, USA)

Montreal

13.45 – 15.30

EMBO Scientific Session

EMBO Plenary session 8: Tissue regeneration, organoids without borders

Chair: Sabine Werner (ETH Zurich, Zurich, CH)

13.45
Fibroblast growth factor: key regulators of epithelial repair and cytoprotection
Sabine Werner (ETH Zurich, Zurich, CH)

14.10
Self-organization and symmetry breaking in intestinal organoid development
Prisca Liberali (Friedrich Miescher Institute for Biomedical Research, Basel, CH)

14.35
Single cell analysis of stem cells during development, homeostasis and repair
Cédric Blanpain (Université Libre de Bruxelles, Brussels, BE)

15.00
Disease modelling in organoids
Marc van de Wetering (Princess Máxima Center Pediatric Oncology, Utrecht, NL)

Montreal