Monday, 09 September 2019
16.45 – 18.00
EMBO Session
Welcome and Opening Lecture at the Basel Town Hall
Chair: Michael Hall(University of Basel, CH)
Welcome
Lukas Engelberger (Basel Stadt, Basel, CH)
Opening Lecture - Climate Crisis: How much can we bear?
Thomas Stocker (University of Berne, Berne, CH)
Offsite
18.00 – 19.30
EMBO Session
Welcome reception
Offsite
Tuesday, 10 September 2019
09.00 – 09.45
Joint Session
Keynote lecture 1: The Genetics of Common Diseases
Kari Stefánsson (deCODE Genetics, Reykjavik, ISL)
Chair: Geneviève Almouzni (Institut Curie, Research Center UMR 3664 CNRS, Paris, FR)
Montreal
10.00 – 11.45
EMBO Scientific Session
EMBO Plenary session 1: Microbiome as a driver of health and disease
Chair:Yasmine Belkaïd (Bethesda, US)
10.00
Host Micro Biome interactions in health and disease
Eran Elinav (Weizmann Institute of Science, Rehovot, IL)
10.25
Microglia at the crossroads of brain circuits and environmental signals
Sonia Garel (PSL Research University, Paris, FR)
10.50
Small molecules from the human microbiota
Michael A. Fischbach (UCSF, San Francisco, US)
11.15
Microbiota control of tissue immunity and repair
Yasmine Belkaïd (Bethesda, US)
Montreal
11.45 – 13.15
Lunch break
13.15 – 15.00
EMBO Scientific Session
EMBO Plenary session 2: The emergence of infectious diseases
Chair: Elena A. Levashina (Vector Biology Unit Max Planck Institute for Infection Biology, Berlin, DE)
13.15
Digital Epidemiology
Marcel Salathé (EPFL, Geneve, CH)
13.40
Experimental and Computational Approaches for Manipulating Virus Evolution and Population Dynamics
Marco Vignuzzi (Institut Pasteur, Paris, FR)
14.05
Title to be announced
Elena A. Levashina (Vector Biology Unit Max Planck Institute for Infection Biology, Berlin, DE)
14.30
Title to be announced
Rino Rappuoli (GSK Vaccines, Siena, IT)
Montreal
15.30 – 16.30
Joint Session
EMBO & [BC]2 Flashtalks on the stage
Stage
16.30 – 17.30
Joint Session
Louis-Jeantet Prize lectures
Chair:
Paul Nurse (The Francis Crick Institute, London, United Kingdom)
16.30
Advanced Genetic Engineering of Hematopoiesis to Treat Human Diseases
Luigi Naldini (San Raffaele Telethon Institute for Gene Therapy, Milan, IT)
17.00
Restoring Vision
Botond Roska (Institute of Molecular and Clinical Ophthalmology Basel (IOB), Basel, CH)
Montreal
15.30 – 16.30
EMBO Session
Networking event & Poster session for EMBO and [BC]2 Presenters
Stage
Wednesday, 11 September 2019
09.00 – 09.45
Joint Session
Keynote lecture 2: Michal Schwartz (Weizmann Institute of Science, Rehovot, ISR)
Chair: Caetano Reis e Sousa (Immunobiology Laboratory The Francis Crick Institute, London, UK)
Montreal
10.00 – 11.45
EMBO Scientific Sessions
EMBO Plenary session 3: EMM lecture and awards
Chair: Philippe Sansonetti & Céline Carret
10.00
A new way to look at Alzheimer’s Disease: the cellular phase
Bart de Strooper (VIB Center for Brain & Disease Research, UK Dementia Research Institute, Leuven, BE)
EMM 10th anniversary award for posters and one speaker per topical session
10.40
Integrated stress response remodels macrophage immune-metabolism to propagate chronic inflammation and atherosclerosis
Ebru Erbay, Cedars-Sinai Medical Center, Los Angeles, USA)
10.50
Detecting the mutational signature of homologous recombination deficiency in clinical samples
Doga C. Gulhan, Harvard Medical School, Boston, United States
11.00
Suppression of arginine catabolism promotes liver cancer
Dirk Mossmann, Biozentrum, University of Basel, Basel, Switzerland
11.10
Penile microbiota of heterosexual black South African men and analysis of abundances of bacteria associated with HIV risk
Harris Onywera, University of Cape Town, Cape Town, South Africa
11.20
Vitamin D modulates macrophage polarization and ER stress in lung inflammation and injury targeting miR-34a/Sirt1 axis
Mansoor Syed, Jamia Millia Islamia, New Delhi, India
11.30
Award
Montreal
11.45 – 13.15
Lunch break
13.15 – 15.00
EMBO Scientific Session
EMBO Plenary session 4:Chronic inflammation: The common denominator of post-modern pathologies
Chair: Alberto Mantovani (Istituto Clinico Humanitas, Milan, IT)
13.15
Trained immunity: potential target in immune-mediated diseases
Mihai G. Netea (Radboud University Medical Center, Nijmegen, NL)
13.40
Neuronal regulation of innate lymphocytes
Henrique Veiga-Fernandes (Centro Champalimaud, Lisbon, PT)
14.05
T cell metabolism in infection and cancer
Erika Pearce (Max Planck Institute for Immunobiology and Epigenetics, Freiburg, DE)
14.30
Molecular pathways linking innate immunity, inflammation and cancer
Alberto Mantovani (Istituto Clinico Humanitas, Milan, IT)
Montreal
15.30 – 17.15
EMBO Scientific Session
EMBO Plenary session 5: Regenerative medicine
Chair: Alain Fisher (Institut Imagine, Paris, FR)
15.30
Mendelian genetics of autoimmunity
Alain Fischer (Institut Imagine, Paris, FR)
15.55
Human type I interferonopathies
Yanick J. Crow (MRC Institute of Genetics & Molecular Medicine, Edinburgh, UK)
16.20
Cellular plasticity in cardiovascular regeneration and aging
Stefanie Dimmeler (Centre for Molecular Medicine, Frankfurt , DE)
16.45
Epigenetic regulation in development, aging and disease
Rudolf Jaenisch (Whitehead Institute for Biomedical Research, Cambridge, USA)
Montreal
Thursday, 12 September 2019
09.00 – 10.15
Joint session [BC]2/EMBO
Plenary session 6: Computational biology, artificial intelligence and machine learning in precision medicine
Chair: Jan Korbel (Genome Biology Unit EMBL, Heidelberg, DE)
09.00
Machine learning approaches for elucidating complex gene-environment interactions
Oliver Stegle (European Bioinformatics Institute, Hinxton, UK)
09.25
Understanding chronic blood diseases using millions of electronic health records and single cell genomics
Amos Tanay (Rehovot, ISR)
09.50
Pinpointing disease-causing regulatory genetic variants by multi-omics and machine learning
Julien Gagneur (Fakultät für Informatik, Technische Universität München, Munich, DE)
10.15
Coffee break
Montreal
10.45 – 12.30
EMBO Scientific Session
Plenary session 7 - Genetic diseases: genome and epigenome
Chair: Kristian Helin (Memorial Sloan Kettering Cancer Center, New York, USA)
10.45
Unraveling the acute stress response in bony vertebrates
Gérard Karsenty (Columbia University Medical Center, New York, USA)
11.10
Combined cell and gene therapy for Epidermolysis Bullosa
Michele De Luca (Università degli Studi di Modena e Reggio Emilia, Modena, IT)
11.35
Why are diseases tissue-specific? Lessons from mitochondrial diseases
Anu Suomalainen (University of Helsinki, Helsinki, FI)
12.00
Epigenetics in transcriptional control, development and cancer
Kristian Helin(Memorial Sloan Kettering Cancer Center, New York, USA)
Montreal
13.45 – 15.30
EMBO Scientific Session
EMBO Plenary session 8: Tissue regeneration, organoids without borders
Chair: Sabine Werner (ETH Zurich, Zurich, CH)
13.45
Fibroblast growth factor: key regulators of epithelial repair and cytoprotection
Sabine Werner (ETH Zurich, Zurich, CH)
14.10
Self-organization and symmetry breaking in intestinal organoid development
Prisca Liberali (Friedrich Miescher Institute for Biomedical Research, Basel, CH)
14.35
Single cell analysis of stem cells during development, homeostasis and repair
Cédric Blanpain (Université Libre de Bruxelles, Brussels, BE)
15.00
Disease modelling in organoids
Marc van de Wetering (Princess Máxima Center Pediatric Oncology, Utrecht, NL)
Montreal
16.00-16.45
Join Keynote Lecture 3: Vasant Narasimhan (Chief Executive Officer of Novartis, Basel, CH)
"Reimagining medicine: The power of data science and digital technologies"
Chair: Susan Gasser (Friedrich Miescher Institute, Basel, CH)
Montreal