BASEL LIFE 2019

9–12 September 2019

Congress Center Basel
Switzerland

Cellular allergy

Date

Thursday, 12 September 2019

Chairs

Michael A. Gerspach (BÜHLMANN Laboratories, Switzerland)
Christian B. Gerhold (BÜHLMANN Laboratories, Switzerland)

Abstracts

Allergic reactions are common phenomena during which the immune system overreacts to typically harmless substances from the environment. These hypersensitivities are mostly mediated by IgE antibodies that recognize the allergen and then trigger a cellular reaction that may lead to a severe and possibly lethal anaphylactic shock.
This innovation forum at BASEL LIFE 2019 on cellular allergy shall be a platform to present cutting-edge research on cellular allergy and its implication in immunotherapy together with novel in vitro approaches in allergy diagnostics and therapy monitoring. The transition from in vivo oral food challenges or skin-prick tests to in vitro assays based on basophil activation as well as expected FDA clearances of oral immunotherapies are current game changers in allergy diagnostics and treatment. Additionally, the role of IgE directed immunotherapy (Omalizumab, Xolair®) as stand-alone and synergistic treatment will be discussed. Concomitant monitoring of therapy success with ex vivo challenges is expected to alleviate the burden on allergy patients significantly. The basophil activation test provokes a patient-specific allergic reaction in a test tube mediated by PI3 like kinase signaling of blood cells. This allows its application beyond allergy monitoring as for instance the Bruton’s kinase inhibitor Ibrutinib (IMBRUVICA®), which is used to treat various lymphoma and leukemia, was discovered using a basophil stimulation assay. Therefore, the innovation forum also aims to present novel discoveries in cellular allergy signaling and their exploitation beyond allergy treatment.

Forum Part 1: Novel strategies for allergy treatment and monitoring Chair: Dr. Michael A. Gerspach (BÜHLMANN Laboratories AG)

Forum Part 2: Cellular signaling in allergy and beyond Chair: Dr. Christian B. Gerhold (BÜHLMANN Laboratories AG)

Thursday, 12 September 2019

9.00 – 15.30

Part 1: Novel strategies for allergy treatment and monitoring

09.00
Introduction

09.15
Cellular Allergy and novel therapy approaches
PD. Dr. Alexander Eggel (University Hospital, Bern Switzerland)

09.45
Recent breakthroughs in immunotherapy of allergy
Dr. Wayne Shreffler (Massachusetts General Hospital, Boston USA)

10.15
Break

10.45
Molecular and functional differences of anti-IgE antibodies ligelizumab and omalizumab
Dr. Christoph Heusser (NIBR Basel, Switzerland)

11.15Novel approaches for allergy diagnosis and immunotherapy monitoring Dr. Alexandra Santos (King´s College, London, United Kingdom)11.45BreakPart 2: Cellular signaling in allergy and beyond12.00How allergens become allergic – the role of the alarmin cytokine IL-33 in allergen sensing Prof. Dr. Jean-Phillipe Girard ( Institut de Pharmacologie et de Biologie Structurale (IPBS), Toulouse, France)12.30Orchestrating signaling in allergic inflammationProf. Dr. Matthias Wymann (University of Basel, Basel, Switzerland)13.00Lunch Break & Industry Symposia14.30PI3K Signalling in Allergic Asthma and COPD Dr. Augustin Amour (GSK, Stevenage, United Kingdom)15.00                        

 

15.00
Use of PI3K inhibitors to prevent cellular and clinical allergic respones
Prof. Dr. Bruce Bochner (Northwestern Medicine, Chicago, USA)

Room Rio