BASEL LIFE 2019

9–12 September 2019

Congress Center Basel
Switzerland

Peptide therapeutics

Date

Tuesday & Wednesday, 10-11 September 2019

Chairs

Thomas Vorherr (Novartis, Basel, Switzerland)
Roderich Süssmuth (Technical University Berlin, Germany)

Abstract

The framework of the BASEL LIFE, we will host the “Peptide therapeutics forum 2019” for 2 days on September 10, and 11. Similar to previous events, presentations highlight important new insights regarding the drug discovery of peptides including examples for successful development. The first day is dedicated to topics to be addressed more early during peptide optimization, and the second day focuses more on issues related to later-stage development. As in the past, this event is thought to disseminate information on latest news in the broad field of therapeutic peptides and to enable networking of interested parties from academia and industries.

Tuesday, 10 September 2019

10.00 – 16.30

10.00
Playmolecule, a repository of deep learning based applications for biomolecule design
Franck Chevalier (Acellera, Barcelona, Spain)

10.30
Optimization of the lipopeptide arylomycin natural product into Gram-negative antibiotics
Christopher Heise (Genentech Research & Early Development, San Francisco, United States)

11.00
Break

11.30
Activation of the Hippo pathway via targeting of transcription factor TEAD using designed tertiary protein structure mimetics
Helene Adihou (Astra Zeneca, Dortmund, Germany)

12.00
Elimination of Aβ oligomers by the orally available all-D-peptide PRI-002 reverses cognition deficits and decelerates neurodegeneration
Dieter Willbold (University of Düsseldorf, Germany)

12.30
Lunch break and Industry Symposium

14.00
PLENARY LECTURE
The chemical evolution of endocrine hormones

Richard DiMarchi (University of Indiana, Bloomington, United States)

15.00
Break

15.30
Peptide platforms for therapy and imaging: The first total synthesis of amanitin for ADCs and one-step 18F-labeling PET-oncology
David Perrin (University of British Columbia, Vancouver, Canada)

16.00
Virobiome derived anti-inflammatory short peptides

Michael Ruff (Creative BioPeptides)

16.30
Title to be announced

Speaker to be announced (Gyros Protein Technologies)

 

 

Room Rio

Wednesday, 11 September 2019

10.00 – 16.30

10.00
Exotic side chain-to-side-chain cyclization modes in octreotide analogs for tumor pretargeting
Anna Maria Papini (University of Florence, Italy)

10.30
Peptide-based radiopharmaceuticals for cancer imaging and therapy
Agonist or Antagonist? Does it really matter?

Melpomeni Fani (University Hospital Basel, Switzerland)

11.00
Break

11.30
Vancomycin regains effectiveness for resistant bacteria by conjugation to cationic peptides         Walter Mier (University of Heidelberg, Germany

12.00
Peptide discovery at protagonist therapeutics: A platform yielding multiple clinical candidates
Mark Smythe (Protagonist, Newark, United States)

12.30
Lunch break and Industry Symposium

14.00
Disulfide-rich peptide production
Mike Pennington (AmbioPharm, North Augusta, United States)

14.30
A new green solvent for solid phase peptide synthesis
Jon Collins (CEM, Matthews, United States)

15.00
Break

15.30
Synthetic immune system engagers target cancer cells and prevent tumor formation         
Christian Becker (University of Vienna, Austria)

16.00
Discovery and clinical development of an inhaled cyclic peptide elastase inhibitor for the treatment of cystic fibrosis
Roxana Drake & Marc Thommen (Santhera Pharmaceuticals CH Ltd., Pratteln, Switzerland)

Room Rio

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